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🔥 Top post: An exciting new paper by researchers at Genentech led by Erin Du · 15 likes + reposts
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Thrilled to share our #OpenAccess online resource "An Introduction to Medicinal Chemistry & Molecular Recognition" on @OpenLibraryON! We designed this resource to provide budding medicinal chemists with the knowledge & tools to navigate sm…
Check out our preprint on an #AI-powered #ligandability prediction platform for bottom-up analysis of #chemoproteomic data to identify #covalent binding sites, including cryptic sites, for the discovery of novel drug targets.
#proteomics #…
Thrilled to share our story on the first rationally designed #covalent #HDAC inhibitor! YSR734 uses an SNAr-reactive electrophile to engage a noncatalytic nitrosylation site cysteine in #HDAC2, showing in vitro activity in AML & #DuchenneM…
#Job alert! We're #hiring a Laboratory Technician at the Centre for Medicinal Chemistry (#CMC) @UTM !
Join the forefront of small-molecule therapeutic discovery as an integral member of our team!
Learn more and apply by Nov 28 here:
https:…
The Centre for Medicinal Chemistry (CMC) at @UTM is hiring an Administrative Assistant! For more information or to apply, read the full job posting here:
https://jobs.utoronto.ca/job/Mississauga-Administrative-Assistant-ON/575276617/
The mystery of @genentech's monovalent BRD degraders equipped with a propargyl "degradation tail" has been solved by researchers @abbvie: a #CRISPR screen reveals molecular glue-like recruitment of #DCAF16.
#TargetedProteinDegradation #Mon…
Granted, the test case is—you guessed it—#BRD4. Nevertheless, this could be an exciting new #TPD modality if it is generalizable to other target proteins, such as those lacking accessible lysines or for which #ubiquitination is slow or ine…
And it's wonderful to see that our alumnus Gary Tin and the amazing Georg Winter wrote the News & Views piece on this paper! #gunningalumni
https://www.nature.com/articles/s41589-022-01217-x
Interesting work by Samy Meroueh @IUMedSchool on the development and characterization of reversible #covalent cyanamide antagonists of TEAD-YAP1 that engage a conserved cysteine palmitoylation site in #TEAD.
https://pubs.acs.org/doi/abs/1…
Feel free to give us a follow here (or on the bird site @gunninglabuoft) to keep up with the latest research and news from our group and to see posts about cool new papers in #medchem, #chemicalbiology, and #drugdiscovery!
Our recent work has focused on the development of small-molecule inhibitors for #HDAC enzymes as well as the "undruggable" transcription factors #STAT3 and #STAT5 as potential treatments for hematological malignancies and other cancers.
h…
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